2024Äê1ÔÂ22ÈÕ£¬Öйú¹ú¼ÒÒ©Æ·¼à¶½¹ÜÀí¾ÖÒ©Æ·ÉóÆÀÖÐÐÄ£¨CDE£©¹ÙÍø¹«Ê¾£¬À´Àû¹ú¼Êw66¹Ù·½ÍøÕ¾ÖйúÒÔ×¢²á·ÖÀà5.1ÀàÉ걨µÄ¶àÌæŵÀ×ƬÉÏÊÐÉêÇëÒÑ»ñµÃÊÜÀí1¡£¶àÌæŵÀ×Ƭ£¨Dotinurad£¬ÉÌÆ·Ãû£ºÓÅÀÖ˼£©ÊÇÒ»¿î´ÙÄòËáÅÅйҩ£¬´ËÇ°ÒѾÓÚ2020ÄêÔÚÈÕ±¾ÉÏÊУ¬ÓÃÓÚÖÎÁƸßÄòËáѪ֢ºÍÍ´·ç2¡£
Í´·çÊÇÓɵ¥ÄÆÄòËáÑγÁ»ýÔÚÊàŦËùÖµľ§ÌåÏà¹ØÐÔÊàŦ²¡£¬Ä¿Ç°ÎÒ¹úµÄ»¼²¡ÂÊΪ1% ~ 3%£¬²¢³ÊÖðÄêÉÏÉýÇ÷ÊÆ¡£Í´·ç³ýÁËÔÚ¼±ÐÔ·¢×÷ÆÚ·¢Éú¾çÁÒÌÛÍ´£¬¶ÔÊàŦÔì³ÉË𺦣¬»¹»á°é·¢ÉöÔಡ±ä¼°ÆäËû´úл×ÛºÏÕ÷µÄÌåÏÖ£¬Èç¸ß֬Ѫ֢¡¢¸ßѪѹ¡¢ÌÇÄò²¡ºÍ¹ÚÐIJ¡µÈ3¡£¹ý¸ßµÄѪÄòËáˮƽ£¨¼´¸ßÄòËáѪ֢£©ÊÇ·¢ÉúÍ´·çµÄ×îÖØÒªµÄΣÏÕÒòËØ4¡£
¶àÌæŵÀ×ÊÇÒ»ÖÖÐÂÐÍÍ´·çÖÎÁÆÒ©Îͨ¹ýÑ¡ÔñÐÔÒÖÖÆÓëÉöÔàÖÐÄòËáÖØÎüÊÕÓйصÄÄòËáÑÎתÔËÂÑ°×£¨URAT1£©£¬ÒÖÖÆÄòËáÖØÎüÊÕ²¢½µµÍѪÄòËáˮƽ5¡£×÷ΪһÖÖURAT1Ñ¡ÔñÐÔÒÖÖƼÁ£¬¶àÌæŵÀ×ÓÐЧÒÖÖÆÉö½ü¶ËС¹ÜURAT1¶ø²»Ó°ÏìÄòËáÅÅйÒò×ÓABCG2ºÍOAT1/3µÄ¹¦Ð§£¬Ïà±È·ÇÑ¡ÔñÐÔURAT1ÒÖÖƼÁ½µÑªÄòËáµÄЧÂʸü¸ß2¡£
¾ÝϤ£¬À´Àû¹ú¼Êw66¹Ù·½ÍøÕ¾ÔÚÖйú¿ªÕ¹ÁËÒ»ÏîÖ¼ÔÚÆÀ¹À¶àÌæŵÀ׺ͷDz¼Ë¾ËûÖÎÁÆÍ´·çÁÆЧµÄ3ÆÚÁÙ´²Ñо¿£¨NCT05007392£©¡£¸ÃÑо¿ÄÉÈë451ÀýÍ´·ç»¼Õߣ¬Ëæ»ú·ÖΪ¶àÌæŵÀ× 4mg×éºÍ·Ç²¼Ë¾Ëû 40mg×飬Ö÷ÒªÑо¿ÖÕµãÊÇÖÎÁÆ24ÖÜѪÄòËáˮƽ¡Ü 6.0 mg/dLµÄ»¼Õß°Ù·Ö±È6¡£´ËÇ°ÔÚÈÕ±¾¿ªÕ¹µÄÒ»Ïî3ÆÚÁÙ´²Ñо¿½á¹ûÏÔʾ£¬¶àÌæŵÀ× 4mgÖÎÁÆ°é»ò²»°éÍ´·çµÄ¸ßÄòËáѪ֢»¼Õߣ¬58ÖÜѪÄòËáˮƽ¡Ü 6.0 mg/dLµÄ»¼Õß´ï±êÂÊ100%£¬ºã¾ÃʹÓöÔÉö¹¦Ð§ÎÞÃ÷ÏÔÓ°Ï죬¶Ô¸Î¹¦Ð§ÎÞÁÙ´²Ïà¹ØÓ°Ïì7¡£
À´Àû¹ú¼Êw66¹Ù·½ÍøÕ¾ÖйúʼÖÕ½«»¼ÕßÀûÒæºÍ¹«ÖÚ½¡¿µ·ÅÔÚÊ×룬Âú×ãÆä¶àÑù»¯ÐèÇó£¬ÎªÌáÉýÆ丣ìí×ö³öТ¾´¡£³ýÁËÖÎÁÆÍ´·çµÄÐÂÒ©¶àÌæŵÀ×£¬À´Àû¹ú¼Êw66¹Ù·½ÍøÕ¾ÖйúÒÑÉÏÊеÄʩάÊæ?£¨ÌæÆÕÈðͪ½ºÄÒ£©¡¢¹ÌÁ¦¿µ?£¨ËÄÏ©¼×ÝÁõ«Èí½ºÄÒ£©ºÍ²¨ÀûÌØ?£¨À×±´ÀßòÄƳ¦ÈÜƬ£©µÈ¶à¿îÒ©ÎïÔÚÏà¹ØÁìÓò·¢»ÓÐͬ×÷Ó᣶àÌæŵÀ׵ļÓÈ뽫¸»ºñÀ´Àû¹ú¼Êw66¹Ù·½ÍøÕ¾ÖйúÔÚÕâЩÁìÓòµÄ²úÎï¹ÜÏߣ¬»Ý¼°¹ã´ó»¼Õß¡£
²Î¿¼×ÊÁÏ£º
[1] Öйú¹ú¼ÒÒ©¼à¾ÖÒ©Æ·ÉóÆÀÖÐÐÄ£¨CDE£©¹ÙÍø.
[2] Ishikawa T, et al. Expert Opin Pharmacother. 2021,22(11):1397-1406.
[3] Ð춫, µÈ.?ÖлªÄÚ¿ÆÔÓÖ¾. 2020,59(6):421-426.
[4] Dalbeth N, et al. Lancet. 2021,397(10287):1843-1855.
[5] À´Àû¹ú¼Êw66¹Ù·½ÍøÕ¾Öйú. 2020-02-25 from https://mp.weixin.qq.com/s/CC5rg1feoMe0WVBR66t-_w
[6] ÃÀ¹úÁÙ´²ÊÔÑé×¢²á¿â from https://classic.clinicaltrials.gov/ct2/show/study/NCT05007392?term=dotinurad&cond=gout&draw=2&rank=1
[7] Hosoya T, et al. Clin Exp Nephrol. 2020;24(Suppl 1):80-91.
Copyright(c) 2011 Eisai China lnc.All Rights Reserved. »¦ICP±¸11005394ºÅ-1 »¦¹«Íø°²±¸31010602001439ºÅ
021-62881220
? Ò©´ú´æ°¸ÐÅÏ¢²éѯ ? ÒÑÉÏÊÐÌæÆÕÈðͪ½ºÄÒ¸õÏÞÁ¿¼ìÑé³ÂËß¹«Ê¾ËµÃ÷
? Ö´·¨Í¨¸æ ? Òþ˽Õþ²ß ? ¿ÉÓÃÐÔ
±¾ÍøվʹÓÃCookiesÒÔʹÄú»ñµÃ×î¼ÑµÄÌåÑ顣ΪÁ˼ÌÐøä¯ÀÀ±¾ÍøÕ¾£¬ÄúÐèͬÒâÎÒÃǶÔCookiesµÄʹÓá£ÏëÒªÁ˽â¸ü¶àÓйØÓÚCookiesµÄÐÅÏ¢£¬»ò²»Ï£Íûµ±ÄúʹÓÃÍøվʱ·ºÆðcookies£¬ÇëÔĶÁÎÒÃǵÄCookiesÉùÃ÷£¡
ÎÒÃÇ¿ÉÄÜ»áÒªÇóÔÚÄúµÄÉ豸ÉÏÉèÖÃCookie¡£ÎÒÃÇʹÓÃcookiesÀ´¸æËßÎÒÃÇÄúºÎʱ·ÃÎÊÎÒÃǵÄÍøÕ¾£¬ÄúÈçºÎÓëÎÒÃÇ»¥¶¯£¬¸»ºñÄúµÄÓû§ÌåÑ飬ÒÔ¼°ÈçºÎ¶¨ÖÆÄúÓëÎÒÃÇÍøÕ¾µÄ¹Øϵ¡£
µã»÷²îÒìµÄÀà±ð±êÌâÒÔÁ˽â¸ü¶àÐÅÏ¢¡£ÄãÒ²¿ÉÒԸıäÄãµÄһЩƫºÃ¡£Çë×¢Ò⣬×èֹijЩÀàÐ͵ÄCookie¿ÉÄÜ»áÓ°ÏìÄúÔÚÎÒÃÇÍøÕ¾ÉϵÄÌåÑéÒÔ¼°ÎÒÃÇËùÄÜÌṩµÄ·þÎñ¡£
ÕâЩ Cookie ÊÇΪÄúÌṩͨ¹ýÎÒÃǵÄÍøÕ¾ÌṩµÄ·þÎñ²¢Ê¹ÓÃÆäijЩ¹¦Ð§µÄÑϸñÐëÒªÌõ¼þ¡£
ÕâЩcookies¾ø¶ÔÓÐÐëҪΪÄúÌṩͨ¹ýÎÒÃÇÍøÕ¾ÌṩµÄ·þÎñ²¢Ê¹ÓÃÆäÖеÄһЩ¹¦Ð§¡£
ÓÉÓÚÕâЩcookies¾ø¶ÔÊǽ»¸¶ÍøÕ¾Ëù±ØÐëµÄ£¬Òò´ËÄú²»ÄÜÔÚ²»Ó°ÏìÎÒÃÇÍøÕ¾¹¦Ð§µÄÇé¿öϾܾøËûÃÇ¡£Äú¿ÉÒÔͨ¹ý¸ü¸Ää¯ÀÀÆ÷ÉèÖÃÀ´×èÖ¹»òɾ³ýËüÃÇ£¬²¢Ç¿ÖÆ×èÖ¹±¾ÍøÕ¾ÉϵÄËùÓÐCookie¡£
Èç¹ûÄúÏë¾Ü¾ø±ý¸É£¬µ«ÎªÁËÖÆÖ¹ÔÙ´ÎÒªÇóÄú£¬ÎÒÃÇÍêÈ«×ðÖØ£¬ÇëÔÊÐíÎÒÃÇ´æ´¢±ý¸É¡£Äú¿ÉÒÔËæʱѡÔñÍ˳ö»òÑ¡ÔñÆäËû Cookie ÒÔ»ñµÃ¸üºÃµÄÌåÑé¡£Èç¹ûÄú¾Ü¾ø Cookie£¬ÎÒÃǽ«É¾³ýÎÒÃÇÓòÃûÖеÄËùÓÐÉèÖà Cookie¡£
ÎÒÃÇΪÄúÌṩÄúËù´æ´¢µÄ Cookie ÁÐ±í£¬ÒÔ±ãÄú¼ì²ìÎÒÃÇ´æ´¢µÄÄÚÈÝ¡£³öÓÚÄþ¾²ÔÒò£¬ÎÒÃÇÎÞ·¨ÏÔʾ»òÐÞ¸ÄÀ´×ÔÆäËûÓòµÄ Cookie¡£Äú¿ÉÒÔÔÚä¯ÀÀÆ÷Äþ¾²ÉèÖÃÖмì²éÕâЩÄÚÈÝ¡£
ÎÒÃÇ»¹Ê¹ÓòîÒìµÄÍⲿ·þÎñ£¬ÈçGoogle Webfonts¡¢Google MapsºÍÍⲿÊÓƵÌṩÉÌ¡£ ÓÉÓÚÕâЩÌṩÉÌ¿ÉÄÜ»áÊÕ¼¯ÄúµÄ IP µØÖ·µÈ¸öÈËÊý¾Ý£¬Òò´ËÎÒÃÇÔÊÐíÄúÔÚ´Ë´¦×èÖ¹ÕâЩÊý¾Ý¡£Çë×¢Ò⣬Õâ¿ÉÄÜ»áÑÏÖؽµµÍÎÒÃÇÍøÕ¾µÄ¹¦Ð§ºÍÍâ¹Û¡£ ¸Ä±ä3D¿Õ¼äÖÐͼ²ãµÄ͸ÊÓ¡£
¹È¸èÍøÂç×ÖÌåÉèÖãº
¹È¸èµØͼÉèÖÃ
Google reCaptchaÉèÖãº
Vimeo ºÍ Youtube ÊÓƵǶÈ룺
Äú¿ÉÒÔÔÚÎÒÃǵÄÒþ˽Õþ²ßÒ³ÃæÏêϸÁ˽âÎÒÃǵÄCookieºÍÒþ˽ÉèÖá£